Equipe 7 : Bases synaptiques des maladies du cerveau (Mameli)

Bases synaptiques des maladies du cerveau


The Mameli lab moved to Université de Lausanne


An unpredicted salient event – rewarding or aversive – triggers a rapid emotional reaction that has profound impact in making a future choice. The research objective in our lab is to decipher the hierarchical anatomical and functional organization as well as the cellular mechanisms underlying acute perception of reward and aversive events.


Our general interest is to dissect the neuronal circuits implicated in the encoding of salience-related events and to understand the role of synaptic modifications in mediating behavioral adaptations in physiological and pathological states including addiction.

Neurons in the lateral habenula can encode rewarding and aversive stimuli. Recent advances from our lab and others indicate that most of lateral habenula neurons do so via their control of midbrain monoaminergi systems including the dopamine and serotonin system. Furthermore, aberrant activity within the lateral habenula has been suggested to be instrumental for aspects of neuropsychiatric disorders including addiction and depression.


Our laboratory aims at dissecting the neuronal circuits, cellular and synaptic adaptations within habenular circuits by combining

in vitro patch-clamp electrophysiology
in vivo single unit recordings
viral-based anterograde and retrograde tracing
behavioral approaches modelling aspects of depression and addiction


Team leader : Manuel Mameli CR 1 INSERM

Salvatore Lecca Post doctoral fellow
Frank Meye Post doctoral fellow
Massimo Trusel Post doctoral fellow
Kristina Valentinova PhD student
Anna Tchenio PhD student


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